Alzheimer Disease

Anti-A-beta antibodies do not prevent neurofibrillary tangle formation

Published in Health and Medicine Week, June 1st, 2006

Active immunization with anti-A-beta antibodies does not prevent neurofibrillary tangle formation.

According to researchers in Switzerland, "Amyloid beta-peptide (A-beta) containing plaques and neurofibrillary tangles (NFT) are the two major histopathological hallmarks of Alzheimer disease (AD). According to the amyloid cascade hypothesis, deposition of A-beta is an initial and essential step in the pathogenesis of AD, and formation of NFT has been proposed to be caused by increased A-beta levels. Several previous studies revealed that A-beta plaque formation can be reduced or even prevented by active immunization with A-beta preparations or by administration of...

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Source: Health and Medicine Week (2006-06-01)

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