Antitumor Immunity
Glucocorticoid-induced TNF receptor family related gene activation enhances antitumor immunity
Published in Health and Medicine Week, August 14th, 2006
"Glucocorticoid-induced TNF receptor family related protein (GITR) is present on many different cell types. Previous studies have shown that in vivo administration of an anti-GITR agonist mAb (DTA-1) inhibits regulatory T cells (Treg)-dependent suppression and enhances T cell responses," scientists in the United States report.
According to T. Ramirez-Montagut and colleagues at Rockefeller University in New York, "In this study, we show that administration of DTA-1...
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