Oncology
Acute myeloid leukemia and myelodysplastic syndrome find new target of 11q amplification in GAB2
Published in Health and Medicine Week, October 2nd, 2006
According to a study from Austria, "Chromosome arm 11q amplifications involving the mixed lineage leukemia gene (MLL) locus are rare but recurrent aberrations in AML and MDS. We have recently shown that in addition to the MLL core amplicon, independent sequences in 11q23-24 and/or 11q13.5 are coamplified within the same cytogenetic markers in 90% and 60% of patients, respectively."
"Here we further narrow down the minimal amplicon in 11q13.5 to 1.17 Mb by means of semi-quantitative PCR and FISH analyses. The newly defined...
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