Proteomics
Cingulin regulates claudin expression and cell proliferation
Published in Health and Medicine Week, October 2nd, 2006
"In mouse embryoid bodies, mutation of the tight junction protein cingulin results in changes in gene expression. Here, we studied the function of cingulin using a gene silencing approach in Madin-Darby canine kidney (MDCK) cells," wrote L. Guillemot and colleagues, University of Geneva.
"Cingulin-depleted cells show higher protein and mRNA levels of claudin-2 and ZO-3, increased RhoA activity, activation of G(1)/S phase transition, and increased cell density. The...
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