Myocardial Infarction
Acute myocardial infarction protection is conferred by endogenous adrenomedullin
Published in Health and Medicine Week, October 23rd, 2006
"Exogenous administration or transfection of AM affords protection against ischaemia-reperfusion injury. Here we have examined the role of endogenous AM in regulating the development of myocardial infarction," wrote S.A. Hamid and colleagues, University London Royal Veterinary College.
"Wild type (WT) and AM(+/-) mice underwent 30 min regional myocardial ischaemia and 120 min reperfusion. In AM(+/-) hearts, tetrazolium-determined infarct size was greater than in WT controls (27.9±2.0 vs. 17.7±2.4%,...
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