Animal Research

Naked mole-rat is unfazed by oxidative stress

Published in Health and Medicine Week, October 30th, 2006

The long-lived naked mole-rat shows much higher levels of oxidative stress and damage and less robust repair mechanisms than the short-lived mouse, findings that could change the oxidative stress theory of aging.

The new study comparing the naked mole-rat, which has a life span of 28 years, and the mouse, which has a lifespan of three years, will be presented Oct. 8 at The American Physiological Society conference, Comparative Physiology 2006: Integrating Diversity. The results fly in the face of the oxidative stress theory of aging, which holds that damage caused by oxidative stress is a significant contributor to the aging process.

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Source: Health and Medicine Week (2006-10-30)

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