Life Sciences
New life sciences study results reported from Meiji Pharmaceutical University
Published in Health and Medicine Week, January 22nd, 2007
Scientists discuss in "Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition" new findings in life sciences. "Neuritic plaques are the key pathological feature of Alzheimer's disease, and amyloid beta (Abeta) peptides are major component of these plaques. In this study, we demonstrated the influence of aluminum (Al) on the Abeta peptide degradation by cathepsin D," scientists in Kiyose, Japan report.
"Al did not directly affect the cathepsin D activity using small synthetic substrate. However, when Abeta peptides were used as substrate, the apparent inhibitory...
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