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Cancer
Loss of Stem Cells Correlates with Premature Aging in Animal Study
June 18th, 2007
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body’s response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans. This work appears in the inaugural issue of Cell Stem Cell. “The reason we’re seeing the early signs of aging in these mice is that we’re exhausting their ability to renew tissues,” says Eric J. Brown, PhD, Assistant Professor of Cancer Biology. “We believe...
Source: Health & Medicine Week (2007-06-18)
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