Health & Medicine Week
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Angiogenesis
Reports from J. Favier et al highlight recent research in angiogenesis
November 5th, 2007
According to recent research from Montreal, Canada, " HIF2 alpha/EPASI is a hypoxia-inducible transcription factor involved in catecholamine homeostasis, vascular remodelling, physiological angiogenesis and adipogenesis. It is overexpressed in many cancerous tissues, but its exact role in tumour progression remains to be clarified." "In order to better establish its function in tumourigenesis and tumour angiogenesis, we have stably transfected mouse neuroblastoma NIE-115 cells with the native form of HIF2 alpha or with its dominant negative mutant, HIF2a (1 - 485) and studied their phenotype in vitro and in vivo. In vitro studies reveal that HIF2a induces neuroblastoma...
Source: Health & Medicine Week (2007-11-05)
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