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Alcoholism
Examining genetic variations among the Huichol population of Mexico
November 9th, 2009
Alcohol abuse is a leading cause of liver cirrhosis in Mexico. Given that genetics likely play a role in high rates of alcoholic liver disease, researchers analyzed the polymorphisms of alcohol dehydrogenase (ADH1B), aldehyde dehydrogenase (ALDH2) and cytochrome P4502E1 (CYP2E1) in two groups in Mexico: the Mestizos, those with mixed genes, and the Huichols, an indigenous group with no racial admixture. Findings show the Huichols have the highest CYP2E1*c2 allele frequency documented in the world to date, placing them at high genetic risk for alcoholism and alcoholic liver disease. Results will be published in the January 2010 issue of Alcoholism: Clinical &...
Source: Health & Medicine Week (2009-11-09)
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