Molecular Medicine
Research from Yeungnam University, Research Center has provided new data on molecular medicine
Published in Health and Medicine Week, December 13th, 2010
2010 DEC 13 -- Fresh data on molecular medicine are presented in the report 'Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression.' According to a study from Korea, "Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum deprivation through increased expression of FLICE-like inhibitory protein (FLIP)."
"CpG ODN-mediated anti-apoptosis depended on the TLR9-Akt-FoxO3a signaling pathway. Inhibition of TLR9 by...
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