Cholesterol

Research on Cholesterol Published by K.J. Cho et al

Published in Health and Medicine Week, April 18th, 2011

2011 APR 18 -- "Hydroxmethylglutaryl (HMG)-coenzyme A (CoA) reductase inhibitors (statins) lower serum cholesterol but exhibit pleiotropic biological effects that are difficult to ascribe solely to cholesterol depletion. Here, we investigated the effect of lovastatin on protein prenylation and cell signaling," scientists writing in the journal Molecular and Cellular Biology report.

"We show that high concentrations (50 mc M) of lovastatin inhibit Ras, Rho, and Rap prenylation but that therapeutic levels of lovastatin (50 nM to 500 nM) do not. In contrast, depletion of cellular cholesterol by therapeutic levels of lovastatin increased Ras GTP loading...

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Source: Health and Medicine Week (2011-04-18)

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