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Neuroscience

Reports from University of Oxford Advance Knowledge in Neuroscience

Published in Health and Medicine Week, September 5th, 2011

2011 SEP 5 -- Data detailed in "Cortical and thalamic innervation of direct and indirect pathway medium-sized spiny neurons in mouse striatum" have been presented. "The striatum receives major excitatory inputs from the cortex and thalamus that predominantly target the spines of medium-sized spiny neurons (MSNs). We aimed to determine whether there is any selectivity of these two excitatory afferents in their innervation of direct and indirect pathway MSNs," researchers in Oxford, United Kingdom report.

"To address this, we used bacterial artificial chromosome transgenic mice, in which enhanced green fluorescent protein (EGFP) reports the presence of D(1)...

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