Cell Biology
Study Findings from University of Wisconsin Broaden Understanding of Cell Biology
Published in Health and Medicine Week, September 5th, 2011
2011 SEP 5 -- Investigators publish new data in the report "Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion. 'Otoferlin is a large multi-C2 domain protein proposed to act as a calcium sensor that regulates synaptic vesicle exocytosis in cochlear hair cells. Although mutations in otoferlin have been associated with deafness, its contribution to neurotransmitter release is unresolved," researchers in Madison, Wisconsin report.
"Using recombinant proteins, we demonstrate that five of the six C2 domains of otoferlin sense calcium with apparent dissociation constants that ranged from 13-25 M; in the presence of membranes,...
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