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Lenox Hill Hospital, New York

Diffuse alveolar hemorrhage reported after infliximab therapy

Published in Healthcare Finance, Tax and Law Weekly, June 30th, 2004

Infliximab therapy for Crohn disease may trigger alveolar hemorrhaging in some patients.

According to recent research from the United States, "[i]nfliximab (Remicade), a chimeric monoclonal antibody to tumor necrosis factor-alpha (anti-TNF-alpha), is being used with increasing frequency in the treatment of Crohn disease."

"Infliximab's safety profile to date has been good with reported adverse events being mild to moderate," noted S. Panagi and coauthors at Lenox Hill Hospital in New York City. However, the collaborators described "a case of diffuse alveolar hemorrhage after the second infliximab infusion in a patient with Crohn disease."

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