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Technical University of Dresden

Plant-derived hanatvirus virus nucleocapsid protein not immunogenic

Published in Healthcare Finance, Tax and Law Weekly, September 1st, 2004

A hantavirus nucleocapsid protein expressed in transgenic plants was not immunogenic after oral administration.

According to recent research published in the journal Virus Genes, "Transgenic plants expressing foreign genes are suitable systems for the production of relevant immunogens in high amounts that can be used to develop a new generation of vaccines against a variety of infectious diseases. Transgenic tobacco and potato plants expressing the nucleocapsid protein of hantavirus serotype puumala were generated and established. Puumala virus is a human pathogen causing hemorrhagic fever with renal syndrome. To investigate oral immunogenicity of the...

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