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U.S. National Cancer Institute

Inflammatory cytokines referee angiogenic control during inflammation

Published in Healthcare Finance, Tax and Law Weekly, September 1st, 2004

Inflammatory cytokines referee angiogenic control during inflammation.

"Vigorous inflammatory responses are associated with tissue damage, particularly when toxic levels of inflammatory cytokines are produced. Despite proangiogenic factors being present early at sites of inflammation, vascular repair occurs toward the end of the inflammatory response, suggesting modulation of the proangiogenic response. Endogenous inhibitors of angiogenesis induced during acute inflammation are poorly characterized," scientists writing in the Journal of Leukocyte Biology report.

"Here, we looked for endothelial cell-derived modulators of angiogenesis that may...

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