Baker Heart Research Institute, Melbourne
Activation of IP receptors represents a novel approach to preventing hypertrophy
Published in Healthcare Finance, Tax and Law Weekly, October 27th, 2004
According to a study from Australia, "The antihypertrophic action of angiotensin-converting enzyme inhibitors in the heart results partly from local potentiation of bradykinin. We have demonstrated that the antihypertrophic action of bradykinin is mediated by the release of nitric oxide from endothelium and elevation of cardiomyocyte cGMP. Whether other paracrine factors derived from the coronary endothelium, such as prostacyclin (PGI2 ), may act to prevent hypertrophy has not been explored."
R.H. Ritchie and colleagues of the Baker Heart...
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