University of Antwerp, Edegem
Transfected B cells defeat problems linked to dendritic cell-related therapy
Published in Healthcare Finance, Tax and Law Weekly, May 4th, 2005
According to published research from Belgium, "cell-based immunotherapy, in which antigen-loaded antigen-presenting cells (APC) are used to elicit T cell responses, has become part of the search for alternative cancer and infectious disease treatments. Here, we report on the feasibility of using mRNA-electroporated CD40-activated B cells (CD40-B cells) as alternative APC for the ex vivo induction of antigen-specific CD8+ T cell responses."
"The potential of CD40-B cells as APC is reflected in their phenotypic analysis, showing a polyclonal, strongly activated B cell...
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