Shimane University
Transplanted B-stem cells reconstitute bone marrow B-cells after irradiation
Published in Healthcare Finance, Tax and Law Weekly, June 15th, 2005
According to a study from Japan, "Bone marrow cells of 4-week-old CBA/J mice were searched for progenitors that can reconstitute CBA-type B lineage (B220+) cells after transplantation into irradiated (BALB/c x CBA/J) F-1 mice.
"In recipients of B lineage-committed B220+ CD117+ cells, which were CD19+ CD127+ CD25- IgM-, numbers of CBA-type B220+ cells had increased greatly by day 8 after transplantation. This increase stopped by day 10 but cell numbers remained at this level for at least 8 weeks."
"B-cell production in the bone marrow of B220+ CD117+ cell...
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