Istituto Superiore di Sanita, Italy
Engrafted neural stem cells restricted to astrocytic lineage due to inflammatory environment
Published in Healthcare Finance, Tax and Law Weekly, August 30th, 2006
According to recent research from Italy, "In vitro, neural stem cells (NSCs) proliferate as undifferentiated spheroids and differentiate into neurons, astrocytes and oligodendrocytes. These features make NSCs suitable for spinal cord (SC) reconstruction.
"However, in vivo experiments have demonstrated that in the injured SC transplanted NSCs either remain undifferentiated or differentiate into the astrocytic phenotype."
"The microenvironment of the injured SC is believed to play a crucial role in driving the differentiation of...
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