G. d'Annunzio University, Italy
Paclitaxel and docetaxel stimulate doxorubicinol formation in the human heart
Published in Healthcare Finance, Tax and Law Weekly, August 30th, 2006
Researchers in Italy report, "Antitumor therapy with the anthracycline doxorubicin is limited by a dose-related cardiotoxicity that is aggravated by a concomitant administration of the taxane paclitaxel. Previous limited studies with isolated human heart cytosol showed that paclitaxel was able to stimulate an NADPH-dependent reduction of doxorubicin to its toxic secondary alcohol metabolite doxorubicinol."
"Here we characterized that 0.25 to 2.5 mcM paclitaxel caused allosteric effects that...
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