Drug Discovery

Research from Abbott Laboratories in the area of drug discovery published

Published in Healthcare Finance, Tax and Law Weekly, December 13th, 2006

New research, "Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels," is the subject of a report. "1. Drug-induced block of the rapidly activating delayed rectifier K+ current (I(Kr)), encoded by human ether-a-go-go-related gene (hERG), has been linked to acquired long QT syndrome (aLQTS)," scientists in the United States report.

"Hypokalaemia is a recognized risk factor in aLQTS. To further understand why hypokalaemia is a risk factor in aLQTS, we examined the effect of [K+]o on drug block of the hERG potassium channel stably expressed in human embryonic kidney (HEK-293) cells using whole-cell...

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Source: Healthcare Finance, Tax and Law Weekly (2006-12-13)

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