Immunology
Recent studies from EvoGenix Limited add new data to immunology
Published in Healthcare Finance, Tax and Law Weekly, January 10th, 2007
New research, "In vitro improvement of a shark IgNAR antibody by Qbeta replicase mutation and ribosome display mimics in vivo affinity maturation," is the subject of a report. According to recent research from Parkville, Australia, "We have employed a novel mutagenesis system, which utilizes an error-prone RNA dependent RNA polymerase from Qbeta bacteriophage, to create a diverse library of single domain antibody fragments based on the shark IgNAR antibody isotype. Coupling of these randomly mutated mRNA templates directly to the translating ribosome allowed in vitro selection of affinity matured variants showing enhanced binding to target, the apical membrane antigen 1 (AMA1) from...
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