Bone Research
Study findings from Pfizer provide new insights into bone research
Published in Healthcare Finance, Tax and Law Weekly, February 7th, 2007
Investigators publish new data in the report "Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice. It has been hypothesized that activation of peroxisome-proliferator-activated receptor-gamma (PPARgamma) by thiazolidinedione drugs can increase adipogenesis at the expense of osteogenesis, leading to bone loss. However, the reported skeletal effects of these compounds are varied and their effects on cortical bone are unknown," scientists in the United States report.
"In this study, we examined the changes in both cancellous and cortical bone of 6-month-old male mice treated with darglitazone, a potent and selective PPARgamma agonist, at 10...
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