Life Sciences
Researchers at Millennium Pharmaceuticals, Inc. target life sciences
Published in Healthcare Finance, Tax and Law Weekly, May 21st, 2008
Investigators publish new data in the report 'Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro.' "GT-1 murine neuronal cells exposed to an experimental proteasome inhibitor (EPI) for 24h showed increased cell death via a non-apoptotic mechanism, as assessed by TUNEL and DNA fragmentation assays. Immunofluorescence staining demonstrated that EPI induced reorganization and relocation of non-ubiquinated actin microfilaments and microtubules to the perinuclear region in EPI treated cells," scientists in the United States report.
"Immunohistochemistry analysis also demonstrated that...
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