Melanoma

Research from Technion yields new data on melanoma

Published in Healthcare Finance, Tax and Law Weekly, July 15th, 2009

"Peptide Ags presented by class I MHC molecules on human melanomas and that are recognized by CD8(+) T cells are the subjects of many studies of antitumor immunity and represent attractive candidates for therapeutic approaches. However, no direct quantitative measurements exist to reveal their expression hierarchy on the cell surface," scientists writing in the Journal of Immunology report.

"Using novel recombinant Abs which bind these Ags with a peptide-specific, MHC-restricted manner, we demonstrate a defined pattern of expression hierarchy of peptide-HLA-A2 complexes derived from three major differentiation Ags: gp100, Melan-A/Mart-1, and tyrosinase. Studying...

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Source: Healthcare Finance, Tax and Law Weekly (2009-07-15)

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