RNA Research

Findings from Genentech, Inc. advance knowledge in RNA research

Published in Healthcare Finance, Tax and Law Weekly, August 12th, 2009

"Mature neurons have diminished intrinsic regenerative capacity. Axotomy of the peripheral branch of adult dorsal root ganglia (a ''conditioning'' lesion) triggers a transcription-dependent axon growth program," scientists writing in the Journal of Neuroscience report.

"Here, we show that this growth program requires the function of the transcription factor Smad1. After peripheral axotomy, neuronal Smad1 is upregulated, and phosphorylated Smad1 accumulates in the nucleus. Both events precede the onset of axonal extension. Reducing Smad1 by RNA interference in vitro impairs axonal growth, and the continued presence of Smad1 is required to maintain the growth...

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Source: Healthcare Finance, Tax and Law Weekly (2009-08-12)

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