Institute University Hematology, Paris
HTLV-1 budding requires both Nedd4 and Tsg101
Published in Healthcare Mergers, Acquisitions and Ventures Week, August 28th, 2004
"One of the most exciting recent developments in the field of retroviruses is the finding that their Gag proteins hijack cellular proteins from the mutivesicular body (MVB) pathway during the budding process.
"The Gag proteins of oncoretroviruses possess a PPxY motif that recruits a ubiquitin ligase from the Nedd4 family, whereas those of the human immunodeficiency virus interact through a PTAP motif with Tsg101, a protein of the ESCRT-1 complex," researchers in France report.
"It is currently assumed that Nedd4 and Tsg101 represent equivalent entry gates towards the same cellular...
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