Healthcare Mergers, Acquisitions & Ventures Week
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Democritus University of Thrace
BNIP3 levels correlate with the prognosis of non-small cell lung cancer
November 6th, 2004
BNIP3 levels correlate with the prognosis of non-small cell lung cancer. "BNIP3 is a proapoptotic protein regulated by hypoxia-inducible factor 1. We analyzed BNIP3 expression in 105 tumor samples from early operable, non-small lung cancer and the relationship of expression to hypoxia-inducible factor 1-alpha, other hypoxia-regulated pathways, and prognosis. There was strong cytoplasmic expression in >10 % of cells in 40 of 105 cases," researchers in Greece report. "BNIP3 expression was associated significantly with high hypoxia-inducible factor 1-alpha (p=0.003), carbonic anhydrase 9 (p=0.04), and was inversely associated with bcl-2 expression...
Source: Healthcare Mergers, Acquisitions & Ventures Week (2004-11-06)
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