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Chiba University
Low-voltage electroporation augments antiangiogenic cancer gene therapy
November 6th, 2004
Low-voltage electroporation augments antiangiogenic cancer gene therapy. According to a study from Japan, "antiangiogenic factors are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis in vitro and tumor growth in mice. We have demonstrated the synergistic antitumor effect of antiangiogenic genes (mouse angiostatin: pBLAST-mAngio; and mouse endostatin: p-BLAST42-mEndo XV) delivered to tumors by low-voltage electroporation in mouse colon 26 models. A synergistic antitumor effect was strongly suggested by in vivo tumor growth kinetics, as well as in survival studies with the mice." "Reverse transcription-polymerase...
Source: Healthcare Mergers, Acquisitions & Ventures Week (2004-11-06)
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