University of Navarra
NOS-deficient mice exhibit reduced adipose tissue and hypoleptinemia
Published in Healthcare Mergers, Acquisitions and Ventures Week, February 19th, 2005
According to a study from Spain, "The aim of this study was to evaluate the impact of the lack of inducible NO synthase (iNOS) on body weight and adipose tissue mass as well as on plasma leptin and adiponectin in basal conditions and 6 hours after lipopolysaccharide (LPS) administration in mice. Body weight was not different among male, 6-week-old wild-type (WT) and iNOS-/- animals. However, the amount of epididymal white adipose tissue (EWAT) in iNOS-/- mice was significantly reduced (p<0.05)."
"Circulating leptin and leptin mRNA in EWAT were...
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