Tech University of Munich
Screen for leukemia resistance identified mutation pattern for PD166326
Published in Healthcare Mergers, Acquisitions and Ventures Week, April 16th, 2005
According to recent research published in the journal Blood, "In Philadelphia-positive (Ph) leukemia, point mutations within the Bcr-Abl kinase domain emerged as a major mechanism of resistance to imatinib mesylate. We established a cell-based screening strategy for detection of clinically relevant point mutations using Bcr-Abl-transformed Ba/F3 cells. We identified 32 different single-point mutations within the kinase domain of Bcr-Abl."
"The pattern and frequency of mutations in this cell culture-based screen resembled the pattern and...
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