Hvidovre University Hospital
Insulin resistance mechanisms enhance type 2 diabetes risk in HIV lipodystrophy
Published in Healthcare Mergers, Acquisitions and Ventures Week, February 11th, 2006
According to a study from Denmark, "More than 40% of HIV-infected patients on highly active antiretroviral therapy (HAART) experience fat redistribution (lipodystrophy), a syndrome associated with insulin resistance primarily affecting insulin-stimulated nonoxidative glucose metabolism (NOGM(ins)).
"Skeletal muscle biopsies, obtained from 18 lipodystrophic nondiabetic patients (LIPO) and 18 nondiabetic patients without lipodystrophy (NONLIPO) before and during hyperinsulinemic (40 mU center dot m-2 center dot min-1)-euglycemic clamps, were...
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