Addiction Medicine

Ovation, National Institute on Drug Abuse study vigabatrin in cocaine addiction

Published in Healthcare Mergers, Acquisitions and Ventures Week, February 24th, 2007

Ovation Pharmaceuticals, Inc. signed a five-year Cooperative Research and Development Agreement with the National Institute on Drug Abuse (NIDA), a division of the National Institutes of Health, to study the company's novel anticonvulsant product, vigabatrin, for the treatment of cocaine and methamphetamine dependence.

Vigabatrin is believed to block the euphoria associated with cocaine administration in humans and suppress craving by increasing brain levels of gamma-aminobutyric acid (GABA), an inhibitory transmitter in the brain.

Data from extensive animal models of addiction and two proof-of-concept studies in people with chronic cocaine and...

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Source: Healthcare Mergers, Acquisitions and Ventures Week (2007-02-24)

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