Cell Science
Findings from Memorial Sloan Kettering Cancer Center advance knowledge in cell science
Published in Healthcare Mergers, Acquisitions and Ventures Week, May 19th, 2007
Scientists discuss in "Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19" new findings in cell science. According to a study from the United States, "Kit ligand (Kitl), the ligand for the Kit receptor tyrosine kinase, plays important roles in hematopoiesis, gametogenesis and melanogenesis. Kitl is synthesized as a membrane-anchored precursor that can be processed to produce the soluble growth factor."
"Here, we evaluated the role of ADAM (a disintegrin and metalloprotease) metalloproteases in ectodomain shedding of Kitl. We found that both ADAM17 and ADAM19 affect Kitl1...
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