Published in Heart Disease Weekly, August 31st, 2003
Researchers have tried for years to repair damaged hearts with mesenchymal stem cells - a type of stem cell derived from bone marrow. But they achieved only limited success, in part because most of the stem cells die shortly after being transplanted.
Victor Dzau and colleagues writing in the September 2003 issue of Nature Medicine engineered the stem cells to express Akt, a protein that prevents cell death. After growing the stem cells in culture and introducing the Akt gene, the investigators injected the...
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