Cardiovascular Disease
Antisense peptide nucleic acid shows promise for antiangiogenic gene therapy
Published in Heart Disease Weekly, September 21st, 2003
"To investigate antisense peptide nucleic acid (PNA) as a gene therapy for the arterial proliferative diseases," scientists in Japan "designed and examined the effects of an antisense PNA targeting platelet-derived growth factor (PDGF) A-chain on expression of PDGF A-chain and growth of vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats."
"A 15-mer antisense PNA complementary to the initiation codon of rat and human PDGF A-chain mRNA was synthesized and purified by high-performance liquid chromatography," explained N. Fukada and colleagues at Nihon...
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Source: Heart Disease Weekly (2003-09-21)
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