Cardiovascular Disease

Role of oxidative stress in cardiomyocyte apoptosis reviewed

Published in Heart Disease Weekly, February 8th, 2004

The putative role of oxidative stress in cardiac cell apoptosis has been reviewed.

"Cardiomyocyte (CM) apoptosis has been reported in a variety of cardiovascular diseases, including myocardial infarction, ischemia/reperfusion, end-stage heart failure, arrhythmogenic right ventricular dysplasia, and adriamycin-induced cardiomyopathy," scientists in the United States explained. "The role of CM apoptosis in the development and progression of cardiac diseases merits further investigation."

"Cumulative evidence suggests that reactive oxygen species (ROS), which have been implicated in cardiac pathophysiology, can trigger myocyte apoptosis by upregulating...

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Source: Heart Disease Weekly (2004-02-08)

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