Angiology
Elastin induces myofibrillogenesis via VGVAPG domain
Published in Heart Disease Weekly, February 29th, 2004
"A hallmark of vascular smooth muscle cells (VSMCs) is their dynamic ability to assemble and disassemble contractile proteins into sarcomeric units depending upon their phenotypic state," scientists in the United States explained. "This phenotypic plasticity plays an important role during vascular development and in obstructive vascular disease."
"Previously, we showed that the elastin gene product, tropoelastin, activates myofibrillar organization of VSMCs," noted S.K. Karnik and colleagues at the University of Utah. "Recently, others have suggested that elastin does not have...
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Source: Heart Disease Weekly (2004-02-29)
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