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Heart Disease Weekly

Susan Hasty, Publisher

Table of Contents . . . October 17th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Heart Disease Weekly | Other Publications

Angiography - Study examines vascular complications after angiography and PCI

Angiology - Vascular dysfunction caused by oxidative stress is prevented by N-acetylcysteine

Echocardiography - ECG method provides a fast measure of LV volumes and reduces operator dependency

Myocardial Infarction - Findings support smaller, weight-adjusted dose of heparin for some patients

Renal Dysfunction - Renal dysfunction is associated with mortality in patients with heart failure

Abdominal Aortic Aneurysm - Changes in abdominal aortic aneurysm morphology occur after endovascular repair

Agriculture - Genetic modification of linseed produces healthier omega 3 and 6 fatty acids

Allergy Medicine - Agreement signed between pharma companies for allergy, hypertension medications

Angina - Inflammation markers signal rapidly advancing coronary disease

Angiology - Guinea-pig artery can be used to study side-effect potential of migraine drugs

Angiology - Low-risk participants had lower measurable coronary artery calcium later in life

Angiology - Review examines the vascular function of plasminogen activator inhibitor-1

Angiology - Study investigates monitoring of platelet function in preop clopidogrel delivery

Angiology - Study investigates the mechanism of the benefits of fish oil

Angiology - Superficial pseudoaneurysms are often mistaken for unrelated pathologies

Angiology - Two or three kiwi fruit per day reduced platelet aggregation response

Angiology - Vasoconstriction elicited by ergotamine is mediated by 5-HT1B receptors

Antibody Development - Antibodies acquired for use with SuperAntibody Technology platform

Anticoagulant Prophylaxis - Article reviews the epidemiology of venous thromboembolism

Anticoagulants - FDA committee wants more data to support approval of Exanta

Arthritis - VIOXX maker withdraws drug from market

Atherosclerosis - Certain common genetic polymorphisms affect response to atorvastatin

Atherosclerosis - Phenolic extracts from grape seeds, marc inhibit atherosclerosis in animal model

Atherosclerosis - VCAM-1, E-selectin, P-selectin levels are useful for detecting atherosclerosis

Atrial Fibrillation - Myocardial architecture confirmed initiating atrial fibrillation

Biosynthesis - Lipoxygenase pathways participate in progression of cardiovascular disease

Blood Vessel Growth - Scientists demonstrate multipotency of hair follicle stem cells

Business Update - Bayer enters strategic pharmaceuticals alliance

Business Update - Drug companies sign marketing agreement for antibiotic, erectile and other drugs

Cardiac Arrest - Catastrophic disruption in hearth rhythm focus of new search for markers

Cardiac Resynchronization - Left ventricular and biventricular pacing provide quantifiable benefits

Cardiac Safety Monitoring - ECG interpretation company wins $4.1M cardiac safety monitoring contract

Cardiology - 99mTc-CO-MIBI complex synthesized

Cardiology - ALK2 plays an essential role in the development of the cardiac outflow tract

Cardiology - Activation of myofibroblasts by TGF-beta1 may lead to valvular heart disease

Cardiology - Cardiac gene transfer improves myocardial blood flow locally

Cardiology - Echocardiographic features must be carefully defined

Cardiology - Genetic defect is required in neural crest cells and their migratory environment

Cardiology - H2 O2 attenuates Ca2+ accumulation during reoxygenation

Cardiology - Nav 1.5 can be ubiquitinated in heart tissues

Cardiology - Palivizumab epitope appears to be highly conserved

Cardiology - Report analyzes benefits of early thrombolytic therapy

Cardiology - Studies show relation between endothelial dysfunction and coronary events

Cardiology - Study investigates alterations of the autonomic nervous system

Cardiology - Study investigates the mechanism of myocardium protection

Cardiology - Unfractionated heparin will be replaced by better antithrombin agents

Cardiology - Vitamins E and C reduced heart damage caused by methidathion

Cardiology - [3H]mazindol binding is highly selective for norepinephrine transporters

Cardiovascular Devices - Temporal features of ICD-associated survival benefit characterized

Cardiovascular Disease - Alpha B-crystallin inhibits glucose-induced apoptosis in vascular cells

Cardiovascular Disease - Endovascular and treatment of vascular disease clinical trial results presented

Cardiovascular Disease - Nesiritide treatment associated with reduced in-hospital mortality

Cardiovascular Disease - Non-human primate study to research HDL Therapy in cardiovascular disease

Cardiovascular Disease - Research debunks myths about men's health

Cardiovascular Disease - Taurine validated as ischemic injury marker

Cardiovascular Diseases - PAI-1 exhibits unique conformational and functional properties

Cardiovascular Diseases - Screening athletes for conditions that risk sudden cardiac death is challenging

Cardiovascular Disorders - Crucial post-transcriptional events are regulated by chronic hypoxia

Cardiovascular Health - Evidence grows that drinking wine is beneficial for cardiac health

Cardiovascular Health - Review deals with the development of novel antiplatelet compounds.

Cardiovascular Health - Study reviews evidence for aspirin in treatment and prevention of CV disease

Cardiovascular Mortality - No link found between change in coronary heart disease mortality and infections

Cardiovascular Stents - HAp nano-film coating successfully completes safety studies

Cervical Cancer - Pharmaceutical company begins clinical trial for cervical cancer treatment

Chronic Renal Failure - Changing renal function confounds analysis

Chronic Respiratory Failure - Trial studies the effects of home pulmonary rehabilitation

Clinical Trials - Drug company awarded phase 1 study worth $1.5 million in cardiac services

Complementary & Alternative Medicine - Human clinical trial on green tea extract shows cholesterol-lowering effect

Congestive Heart Failure - Inhibition of Ca2+ efflux mode could improve contractility in heart failure

Congestive Heart Failure - Positive preliminary phase II results announced for Furosemide GR

Coronary Artery Bypass - Clinical study results announced for automated coronary anastomotic technology

Coronary Artery Bypass - Off-pump technique safe for second-time heart surgery patients

Coronary Artery Bypass Grafting - Non-invasive assessment of coronary artery bypass grafts reviewed

Coronary Artery Bypass Grafting - Quality of life comparable after initial and repeat CABG

Coronary Artery Disease - Osteoprotegerin gene polymorphisms associate with heart disease in men

Cystic Fibrosis - Companies agree to develop PEGylated secretin for cystic fibrosis

Deep Vein Thrombosis - Advocacy group supports release of updated guidelines for the prevention of DVT

Deep Vein Thrombosis - High prevalence of thrombophilic defects in spontaneous and effort-related UEDVT

Defibrillation - Body mass index is an independent predictor of defibrillation thresholds

Defibrillator - FDA clears HeartStart home defibrillator for over-the-counter sale

Developmental Biology - Analysis illustrates the mechanisms by which Hox genes orchestrate organogenesis

Diagnostics - Company announces latest statewide contract to provide remote ECG screening

Diagnostics - Licensing agreement to facilitate development of imaging agents for diagnostics

Diagnostics - Research shows treadmill test plus risk assessment helps predict mortality

Disease Management - More frequent monitoring advised for people with diabetes

Echocardiography - Hand-carried ECG had 100% sensitivity for detecting acute coronary syndrome

Echocardiography - Myocardial contrast ECG may be useful in routine post-AMI risk stratification

Echocardiography - Study salvaged nondiagnostic TTEs by using ultrasound contrast

End-Stage Renal Disease - Hypertension treatment in hemodialysis patients reviewed

Endocarditis - Half of patients 60 years of age warranted endocarditis prophylaxis

Endocrinology - Circulating mononuclear cells in the obese found to be in proinflammatory state

Epidemiology - Studies point to a pathophysiological basis for atherogenic potential of arsenic

Exercise Physiology - Physical conditioning blunts the effects of nitric oxide synthase deficiency

Finance - Biopharm reports year-end loss of $26 million

Finance - Cardiovascular and vascular device manufacturer reports record sales

Finance - Medical instrument company announces fourth quarter and year-end financials

Fitness & Wellness - Earlier diagnosis, education of heart patients may improve outcomes, poll shows

Fitness & Wellness - Home versions of health club fitness treadmills now available

Food Chemistry - Wild plants contribute to low incidence of atherosclerosis in Mediterranean area

Genomics - ABCA1 mutations have been identified in patients with HDL deficiency

Genomics - Researchers gathered to present completed sequences of three genomes

HIV/AIDS-Associated Disease - HIV-1 Tat increases adhesion of monocytes and T-cells to the endothelium

Healthcare Access - NewYork hospital launches $1 billion capital campaign

Heart Attack - First Washington-based Accredited Chest Pain Center announced

Heart Disease - First patient enrolled in trial of ZoMaxx drug-eluting coronary stent

Heart Disease - Pathogenesis of chronic Chagas disease is an unresolved issue

Heart Disease - Patient enrollment completed for ENDEAVOR III clinical trial

Heart Disease - Plasminogen may influence cardiovascular diseases in a number of ways

Heart Disease Prevention - Researchers find structure of enzyme giving red wine its beneficial properties

Heart Disease Risk - Abused, neglected children more likely to have heart disease as adults

Heart Disease Risk Factor - Coronary risk assessment varies in subjects with type 2 diabetes

Heart Failure - A-HeFT heart failure study added to ADA late-breaking plenary session

Heart Failure - InSync Sentry CRT-D approved for marketing in Canada

Heart Failure - PREDICT study results on heart failure released

Heart Transplantation - Artificial heart pilot trial enrolment completion announced

Heart Valves - Company announces first live implant of new BioPhysio heart valve

Hemodialysis - Disorders of mineral metabolism are associated with mortality in renal patients

Hemodynamic Physiology - Patients should be screened for CV, blood pressure disorders before liposuction

Hormone Replacement Therapy - Catecholamines may abrogate estradiol's antivasoocclusive effects

Hormone Replacement Therapy - E-2, but not phytoestrogen ZAL, directly affects cardiac contractile function

Hypercholesterolemia - Atorvastatin treatment suppressed CD40L and P-selectin expression

Hypercholesterolemia - Dense LDLs originate from two sources in cases of familial hypercholesterolemia

Hypercholesterolemia - Ezetimibe and atorvastatin together were well tolerated and efficacious

Hypercholesterolemia - Jaffa juice positively influences serum lipid, albumin, and fibrinogen levels

Hypercoagulability - Early diagnosis of hypercoagulability may allow pharmacologic intervention

Hypertension - A polymorphism of a gene encoding aldosterone may be linked to hypertension

Hypertension - Capsaicin increased the sensitivity of rat blood pressure to salt

Hypertension - Eurand inks agreement for development of lercanidipine

Hypertension - Increased pulse pressure may explain relation of CVD to systolic blood pressure

Hypertension - Results support recommendations for strict control of blood pressure

Hypertension - Sleep-disordered breathing plays a role in the development of hypertension

Hypothyroidism - Benefits of treating mild thyroid failure with L-thyroxine outweigh the risk

Imaging - Accurate method for interpretation of heart images developed in Finland

Imaging - Method corrects for heart motion by tracking the lung-myocardium interface

Imaging - PET method resamples heart images to a common model

Imaging - Patent announced for diagnostic ultrasound with microsphere imaging

Imaging - Technique maintains perfusion values and improves signal increase

Imaging - Visual analysis of contrast-enhanced-MR imaging studies can assess transmurality

Immunology - Celacade found to reduces cardiac muscle inflammation in preclinical study

In-Stent Restenosis - Impact of the use of sirolimus-eluting stents is evaluated

Information Technology - Comarketing agreement announced between risk management organizations

Information Technology - Sleep apnea council makes information from physicians available on website

Insulin - Insulin-delivery company has developed potential to convert a solitary tumor

Intracardiac Measurement - Mitral A-wave propagation velocity is age independent

Kidney Disease - Chronic kidney disease increases risk of heart disease, stroke, or death

Kidney Transplantation - Data presented on prevention of rejection after kidney transplantation

Lipid Studies - Antagonists of LPA receptors might help to prevent thrombus formation

Lipid Studies - Estradiol possesses a protective effect on the endothelium

Liver Transplantation - Researchers report on 18-year experience of liver transplantation

Lysophospholipids - Author raises questions about the role of lysophospholipids

Marfan Syndrome - Data support aneurysm surveillance and prophylactic surgical intervention

Market Analysis - Drug eluting stent utilization data released

Medical Devices - Cardiac monitoring and arrhythmia management service partners with Medtronic

Medical Devices - Electronics company launches branding campaign

Medical Devices - Imaging technology company releases device for 3-D view of coronary vessels

Medical Devices - Water, enclosures, and tool manufacturing company installs AEDs

Medical Equipment - Flat-panel detector used for cardiac studies and interventional procedures

Medical Facilities - All-digital heart hospital opens in Tulsa, Oklahoma, installs new IT system

Melioidosis - Researcher provide update on B. pseudomallei, "the great mimicker"

Myocardial Development - Differences in the origin of myocardia have implications for heart disease

Myocardial Infarction - Can we learn new tricks from an old drug in treating heart attacks?

Myocardial Infarction - Impairment of microcirculatory function may play a role in ballooning syndrome

Myocardial Infarction - Mitochondrial DNA polymorphism 5178A protects against heart attacks in Japan

Myocardial Infarction - Study documents biventricular reverse remodeling in patients with inferior AMI

Myocardial Infarction - Study evaluates the effect of melatonin on infarct size

Myocardial Infarction - U.S. heart attack patients survive longer than Canadians

Neuroscience - AT2 receptor is downregulated in post-MI ventricular remodelling in the rat

Neuroscience - Blocking of CRF1 receptors attenuates cardiovascular responses to stimuli

Obstetrics - Remifentanil effective anesthesia in parturients with critical aortic stenosis

Obstetrics - Tauroconjugated bile acid levels may be involved in obstetric cholestasis

Osteoporosis - Study suggests potential for vitamin D augmentation of estrogen therapy

Pediatric Obesity - Carotid artery thickening, stiffness found in obese children as young as 7

Pediatrics - Researchers find chronic illnesses among children not adequately addressed

Pericardial Effusion - Hand-carried cardiac ultrasound devices were used for bedside examination

Personnel - Dr. Burton Sobel joins board of alfimeprase maker

Personnel - New member appointed to medical device company's board of directors

Personnel - Pharma company announces addition of vice president of clinical pharmacology

Personnel - Pharmaceutical company names CFO and chief business officer

Plasmingen Activators - tPA participates in a number of events in the central nervous system

Platelet Inhibition - Prostaglandins can be used at lower concentrations to lower side effects

Protein Synthesis - Heparin dose-dependently modulates protein synthesis

Proteomics - Pharma company announces collaboration expansion with Kirin Brewery

Psychotropic Drugs - Licensing agreement for triple uptake inhibitors for depression clears hurdle

Research Publishing - Research spending and English proficiency are associated with publication output

Restenosis - Stent significantly reduces incidence of reblocked heart arteries in women

Sleep Apnea - FDA clears implantable medical device as treatment for sleep apnea

Sleep Apnea - Survey finds Americans don't recognize sleep as critical in maintaining health

Statin Therapy - The effect of statin therapy on NK cell cytotoxicity may contribute to benefits

Stem Cell Research - ESCs established from blastocysts differentiate into cardiomyoctes and neurons

Stem Cell Research - Economic study demonstrates Proposition 71 benefits to California's economy

Stem Cell Therapy - Embryonic SCs contribute to stable beneficial outcome in myocardial infarction

Stress - Anger, hostility, depression linked to high C-reactive protein levels

Survival & Mortality - Company announces two significant studies at HFSA meeting

Systemic Lupus Erythematosus - Disease activity is strongest risk factor for atherothrombosis in lupus

Thrombosis - Updated thrombosis guidelines offer recommendations

Transcutaneous Electrical Nerve Stimulation - TENS improves exercise tolerance and measures of ischemia but not symptoms

Transfection - The Sleeping Beauty transposon steers transgene expression

Vascular Disease - Strain from low aortic wall velocities in vivo can be quantified in vivo

Vascular Disease - Vascular repair and regeneration is regulated by bone-marrow derived cells

Vascular Occlusion - Monocyte chemoattractant protein-1 gene inhibition thwarts in-stent restenosis

Vasodilation - E-2 selectively boosts sensory nociceptor innervation of female rat arterioles

Vector Development - Adeno-associated viral vectors cultivate widespread muscle cell transduction

Ventricular Assist Devices - Global begins for VentrAssist artificial heart

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