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Heart Disease Weekly

Susan Hasty, Publisher

Table of Contents . . . November 7th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Heart Disease Weekly | Other Publications

Cardiac Devices - Biventricular ICDs offer survival benefit compared to biventricular pacing alone

Cardiac Devices - Thin filament is key modulator of contractile performance in failing human heart

Drug Therapy - Large study will evaluate n-3 polyunsaturated fatty acids and rosuvastatin

Heart Failure - The burden of heart failure is greater in ethnic minority populations

Ventricular Fibrillation - Radiofrequency ablation in children with Wolff-Parkinson-White syndrome studied

Abdominal Aortic Aneurysm - Estrogen protects male rats from aneurysm

Abdominal Aortic Aneurysm - FDA approves medical device to treat AAA

Abdominal Aortic Aneurysm - New technique to repair aneurysms safer

Adverse Drug Events - Study suggests caution against using certain drugs to unclog heart arteries

Alzheimer Disease - Pharma company's long-term study of Celebrex expected to continue

Amyotrophic Lateral Sclerosis - CytRx adds three drug candidates with acquisition of Biorex assets

Aneurysm - Company introduces low permeability AAA Device

Angiology - Human endothelial cells from different types of vasculature warrant study

Angiology - System may aid therapies to lower incidence of acute coronary artery diseases

Angioplasty - Augmented beta-endorphin is found in patients with coronary artery disease

Antiphospholipid Syndrome - Abnormal homocysteine metabolism not key factor in autoimmune disorder

Arrhythmias - FDA approves first U.S. implants of Philos II DR-T pacemaker

Arthritis - Research shows gelatine stimulates synthesis of type II collagen

Artificial Hearts - Company addresses possible reimbursement for VentrAssist LVAS

Atherosclerosis - Drug for rheumatism possible boon to heart patients

Atherosclerosis - MRI and spatially enhanced cluster analysis provide method to quantify plaque

Atherosclerosis - Results presented on antibody-based treatment of atherosclerosis

Atherosclerosis Vaccine - Cholesteryl ester transfer protein induces long-lasting antibodies

Atrial Fibrillation - Alcohol consumption may be associated with irregular heartbeat in men

Atrial Fibrillation - Anisotropic, decremental conduction occurs during onset of atrial fibrillation

Atrial Fibrillation - Asymptomatic atrial fibrillation after catheter ablation infrequent

Atrial Fibrillation - Biphasic cardioversion allows comparable success rates with lower energies

Atrial Fibrillation - Wave characteristics were repeatable from ECG to ECG for stable patients

Atrial Flutter - Beta-radiation can create linear lesions that are contiguous and nonthrombogenic

Atrial Tachycardia - Atrial hemodynamic burden is a determinant of sustained ANP response

Autonomic Nervous System - Colic infants do not have abnormal autonomic reactivity to stimuli while asleep

Bacteriology -  Enterococcus faecalis fsr two-component system controls biofilm development

Bacteriology - Swedish company presents mass screening tests at investment conference

Bariatric Surgery - Obesity surgery can cure diabetes, high blood pressure and other ills

Blood Clotting Disorders - Gen-Probe signs licensing agreements

Breast Cancer - Study links low HDL levels with increased risk of postmenopausal breast cancer

Brugada Syndrome - Epicardial cooling could be an in vivo experimental model of Brugada syndrome

Business Update - Cardiology instrument designer and manufacturer added to Russell Indices

Business Update - Medical monitoring service changes stock symbol

Cancer Imaging Technology - Changes made to computed radiography system

Cardiac Anomalies - Toddler with uncommon condition showing improvement

Cardiac Arrest - Ephedrine linked to sudden cardiac death

Cardiac Devices - Long-term monitoring of SvO2 by implanted devices may be feasible

Cardiac Hypertrophy - Responses may influence cardiac performance during eccentric cardiac hypertrophy

Cardiac Monitors - FDA approves marketing a newly developed cardiac monitor

Cardiac Virus Detection - Real-time PCR is an efficient method to detect PVB19 infection in heart tissue

Cardiology - After initial damage, protective mechanisms within the heart were initiated

Cardiology - Columbus Regional Hospital receives Chest Pain Center accreditation

Cardiology - Correlation found between exhaled NO changes with exercise and peak VO2

Cardiology - Electroporation of hepatocyte growth factor DNA treats cardiomyopathy

Cardiology - Endogenous Ang II may modulate inward calcium current in the failing heart

Cardiology - European pharmaceutical awards $1.3M for electrocardiographic services

Cardiology - Heart rate, load effects on viscoelastic properties studied in animal model

Cardiology - LV systolic dysfunction was a strong predictor of mortality and morbidity

Cardiology - New catheter available for crossing chronic total occlusions

Cardiology - New treatment may help prevent blood clots

Cardiomyopathy - P-wave dispersion was higher in patients with dilated cardiomyopathy

Cardiovascular Disease - Biopharmaceutical company announces CARE 2 study

Cardiovascular Disease - Biosciences company enters collaboration to study genetics of heart disease

Cardiovascular Disease - Data on Thelin presented at American College of Rheumatology Meeting

Cardiovascular Disease - Decline in subarachnoid hemorrhage mortality is different in men than in women

Cardiovascular Disease - Prospective cohort study of the MONICA population published in Circulation

Cholesterol - Cholesterol guidelines become a morality play about conflict of interest

Cholesterol - New drug designed to reduce cholesterol levels launched

Congestive Heart Failure - Questionnaire is sensible and valid for estimation of daily energy expenditure

Congestive Heart Failure - Sinus node remodeling is characterized by reduced functional sinus node reserve

Coronary Artery Bypass Grafting - Fasudil attenuates post-CABG coronary artery spasm

Coronary Artery Bypass Grafting - Pericardial/serum myoglobin ratio may mark perioperative myocardial infarction

Coronary Artery Disease - 3-D fusion imaging is useful in decisions about coronary artery disease

Coronary Artery Disease - Ascending aortic BP waveform may be related to CAD risk in women, but not men

Coronary Artery Disease - Pharma company releases phase 1 results for coronary atherosclerosis treatment

Cystic Fibrosis - Company announces final research report on cystic fibrosis treatment

Diabetic Ketoacidosis - Cardiac troponin I concentration increases in diabetic ketoacidosis

Diabetic Nephropathy - Therapies for ventricular hypertrophy compared in diabetic patients

Diabetic Nephropathy - Treating albuminuria may prevent heart disease in diabetic patients

Diagnostics - Life sciences company announces Nanobacteria blood test manufacturing agreement

Disease Management - Program improved management of patients hospitalized for heart failure

Drug Development - Sense oligonucleotides targeting VEGF may help patients with ischemic tissues

Drug Development - Thelin for vascular constriction promising in patients failing bosentan therapy

Drug Therapy - A number of agents can modulate the expression of CD40 ligand

Drug Therapy - Levosimendan activates potassium flux to the mitochondrial matrix

Drug Therapy - Tezosentan at 1-25 mg/h improves hemodynamics and reduces B natriuretic peptide

Drug Therapy - Ventricular function and NYHA class, rather than age, predict low tolerability

Echocardiography - 3D echocardiography can aid selecting a pacing site in resynchronization therapy

Electrocardiography - Estimates of sensitivity and specificity varied greatly in individual studies

Embryonic Development - Connexin expression maintains lens quality and heart function in embryogenesis

Finance - Biotherapeutics announces third-quarter 2004 results

Fitness & Wellness - Medical device company introduces Premium Pedometer

Fitness & Wellness - Online survey shows restaurants struggling to keep dieting customers

Fitness & Wellness - Seapoint Farms introduces dry roasted edamame

Flavonoids - Artichoke flavonoids may represent the ingredients mediating eNOS up-regulation

Flavonoids - Grape seed flavonoids have exhibited antioxidant activity in a number of studies

Generic Drugs - Pharma company makes recommendation for usage of generic Vioxx

Genomics - Deoxyribozymes exhibit the ability to silence disease-associated genes

Gerontology Research - Mitochondrial damage may be associated with depleted CoQ and alpha-tocopherol

HIV/AIDS Therapy - Jury is still out regarding benefits of switching to protease-sparing regimen

HIV/AIDS Therapy - Nevirapine is better than efavirenz at raising "good" cholesterol

Heart Devices - 3F Aortic Bioprosthesis heart valve gets CE mark of conformity

Heart Disease - Canadian biotech company begins two studies on cholesterol combination therapy

Heart Disease - ChromoFlex heart stent receives European medical device approval

Heart Disease - Clinical trials slated for choelsterol drug

Heart Disease - Guidant to initiate vulnerable plaque study

Heart Disease Prevention - American Heart Association urges heart education

Heart Rate Variability - Short-term heart rate variability depended upon the type of exercise

Hormone Replacement Therapy - New guidelines confirm clinical value HRT for menopausal symptoms

Hormone Replacement Therapy - Short-term HRT effects vary among vascular sites

Hypercholesterolemia - MRI can measure early benefits of cholesterol-lowering drugs, plaque reduction

Hypertension - Captopril and L-arginine affect ventilation through different mechanisms

Hypertension - Folate intake lowers women's risk of high blood pressure

Hypertension - Insulin resistance in teens raises high blood pressure risk as adults

Hypertension - Left ventricular mass does not increase if BP is controlled for a long period

Hypertension - Stanford to test effects of drug widely used for pediatric hypertension

ICU Shock - B-type natriuretic peptides may provide useful information in ICU shock

Imaging - 23Na MRI may be a good technique for imaging nonviable myocardium in humans

Imaging - Colorado medical imaging group introduces preventive imaging screening services

Imaging - MRI technique is a reliable method for assessing deposition of iron in the liver

Imaging - Mn2+ ions, ion-releasing contrast media are effective for T1 imaging

Imaging - Study reports on automated quantification SPELT myocardial perfusion images

Inflammatory Reaction - VEGF is a key mediator of angiotensin II-induced vascular inflammation

Information Technology - Data exchange network launched for cardiology monitoring

Ischemia - Ischemia-modified albumin can be affected by skeletal muscle ischemia

Ischemia/Reperfusion - p38 and JNK prevent or promote cell survival in response to SI/R-induced injury

Ischemic Heart Disease - COX-2 inhibition in patients with ischemic heart disease merits investigation

Legal Issues - Implantable chip provides medical information, privacy worries

MR Angiography - Free-breathing navigator-gated method was superior in coronary MR angiography

Macular Degeneration - Pharma company announces data for ocular disorders trial

Medical Devices - Carotid stenting with emboli protection filter in high-risk patients studied

Medical Devices - Electronics company announces partnership, 500th installation of CardioMD

Medical Devices - Heart devices manufacturer comments on increased Medicare reimbursement for VADs

Medical Devices - Laser products utilized during live case sessions at transcatheter convention

Medical Devices - Sensing technology company chooses manufacturer for mobile vital signs system

Mergers & Acquisitions - Medical device company announces completion of Irvine Biomedical acquisition

Myocardial Infarction - Classification could be used to predict LV function at the time of discharge

Myocardial Infarction - Infarct size is a major determinant of high N-BNP levels

Myocardial Infarction - Mild exercise training ensured a beneficial role in the remodeling of the heart

Myocardial Infarction - Simple blood test for kidney function predicts heart attack death

Myocardial Infarction - Spanish trial suggests angioplasty after anticlotting therapy safe, beneficial

Myocardial Ischemia - Slow coronary flow alone may lead to myocardial ischemia

Myocardial Ischemia-Reperfusion - CAPE reduces size of I/R-induced myocardial infarction in rats

Myocardial Perfusion - Semiquantitative parameters have varied sensitivities for perfusion deficits

Natriuretic Peptides - Current assays require refinement

Nutrition - ConsumerLab.com approves Eskimo-3 in testing process

Nutrition - High intake of folates and vitamin B6 is inversely associated with MI risk

Nutrition - Olive consumption contributes to the benefits of the Mediterranean diet

Nutrition - Research shows omega-3 fats benefit cardiovascular health

Nutrition & Exercise - Effects of high-fat diet are prevented or reversed with exercise training

Obesity - America finally holds line on weight, market survey says

Obesity - Company wins phase I SBIR grant for obesity program

Obesity - Study finds nearly 200 million Chinese are overweight

Obesity Surgery - Surgical treatment for obesity appears effective for weight loss

Obstetrics - Tocolysis with beta-mimetic agent normalizes CTG pattern in early labor

Open Heart Surgery - Single postoperative measurement can estimate myocardial cell injury

Opthalmology - Treatment for wet age-related macular degeneration receives new brand name

Orthostatic Tolerance - Packed cell volume is important in determining orthostatic tolerance

Patient Information - Educational website for transmyocardial revascularization launched

Peripheral Arterial Disease - Angiogenesis therapy successful for artery disease

Personnel - Cancer diagnostic company announces new research and development executive

Personnel - Cardiovascular-focused biopharma appoints new CFO

Personnel - Dr. H. William Strauss named chairman of scientific and medical advisory board

Personnel - Drug delivery company appoints nonexecutive directors to the board

Personnel - Gary O. Tegan joins device maker as VP, marketing

Pharmacology - Myosin ATPase inhibitor activates ion channels and Ca2+-handling proteins

Rehabilitation - Shorter rehab stays may be linked with higher death rates

Restenosis - Thirty-day safety data reported from Taxus V drug-eluting stent clinical trial

Sleep Apnea - Study of association between APOE and sleep apnea reveals age dependency

Smoking Ban - Minnesota County approves new restrictions on smoking

Sports Medicine - Augmented metabolic stress was observed when strenuous exercise was repeated

Stem Cell Research - IFATS researchers believe fat stem cells may offer therapeutic potential

Stem Cell Research - Survey shows 3 in 4 Americans support Nancy Reagan's call for stem cell research

Stroke - Infection caused by periodontal pathogens is associated with future stroke

Stroke - Neurologic improvement a week after a stroke indicates later deterioration

Surgical Devices - Results of new heart surgery system discussed at conference

Thermoregulation - Moderate exercise in the cold while hypohydrated does not alter heat production

Thrombolysis - Effect of early vs. late prehospital thrombolysis studied in acute MI

Tissue Engineering - Scaffold topography alters cardiomyocyte network intracellular calcium dynamics

Transfusion Medicine - Reconstituted blood is better for infants' heart surgery than fresh blood

Transplant Medicine - Wisconsin boy receives new internal heart pump for children

Vagal Dysfunction - Stimulation with pyridostigmine may be a therapy option for vagal dysfunction

Vascular Disease - Reduced plasma glutathione levels are a risk factor for cardiovascular disease

Vascular Noradrenaline Sensitivity - Mechanisms may contribute to the protective actions of AT1 blockers

Vitamin Therapy - Vitamin treatment may reduce cardiovascular morbidity and mortality

Wilms Tumor - Evidence that therapy with doxorubicin improves survival remains elusive

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