Heart Disease Weekly
Susan Hasty, Publisher
Table of Contents . . . March 27th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Heart Disease Weekly | Other Publications
Heart Failure - CPU 86017 improved cardiac performance in acute and chronic heart failure
Heart Failure - Candesartan is an important treatment in chronic heart failure
Heart Failure - Focus on symptomatic relief leads to underuse of ACE inhibitors, beta-blockers
Ischemia/Reperfusion - Study investigated effects of sildenatil citrate on ischemia reperfusion injury
Myocarditis - IFN-gamma (KO) mice have greater progression to dilated cardiomyopathy and HF
ACE Inhibitors - Cardioprotection of zofenopril is greater than non-sulphydryl ACE inhibitors
Addiction Medicine - Cocaine hydrolase gene delivery blunts the heart's response to cocaine
Age-Related Macular Degeneration - Company expands clinical testing of AdPEDF for wet AMD
Alcohol Use - Sleep loss increases cardiovascular disease risks in alcoholics
Angina - Exercise tolerance is good screening test for chest pain patients
Angiology - Calcium-independent phospholipase studied, regulation clarified
Atherosclerosis - New findings in atherosclerosis described
Angiology - Inhibiting MMPs could ameliorate intimal thickening, prevent MI
Angiology - Media-like islands protect local sites, not entire artery from atheroma
Angiology - Researchers report details of new studies and findings in the area of angiology
Angiology - Treatments for isolated proximal LAD disease demonstrated good results
Angioplasty - Stenting benefits diabetic patients undergoing angioplasty
Angiotensin - Adrenal glomerulosa cell physiology studied, effect of angiotensin shown
Atherosclerosis - Studies describe new findings in atherosclerosis research
Angiotensinase - Angiotensinase activity studied, asymmetrical brain distribution revealed
Aortic Stenosis - Model identified parameters for improved hemodynamics during SNP infusion
Atherosclerosis - Data advance knowledge in atherosclerosis research
Atherosclerosis - Harvard inks agreement to launch major genotyping study in atherosclerosis
Atherosclerosis - Nobiletin may prevent atherosclerosis by inhibiting foam-cell formation
Cardiology - Reports advance knowledge in cardiology research
Atherosclerosis - Role of SOXF in vascular cells gives insight into response to oxidative stress
Atherosclerosis - Statin effects: location may be key
Atherosclerosis Progression - Lack of social support associated with faster progression of CAD in women
Atherosclerosis Vaccine - Immunomodulation of atherosclerosis reviewed
Business & Finance - Medical device company announces financial results
Cardiology - Researchers detail new studies and findings in the area of cardiology
Business Update - ATP-focused company updates recent drug development and corporate activities
Business Update - Benephit Infusion System receives CE marking; company names Italian distributor
Business Update - Cardiac Science awards contract for lithium battery power packs for AEDs
Business Update - Companies ink agreements relating to engineered-tissue products
Business Update - Conference featured presentations by cardiovascular and cardiology companies
Business Update - Instrumentation company receives signed agreement from LLUMU
Cardiology - Studies advance knowledge in cardiology research
Business Update - Medical device company to close vascular bracytherapy business
COX-2 Inhibitors - Patients on COX-2 inhibitors should have an assessment of any CV risk factors
Cardiac Cell Therapy - Review details clinical potential of stem cell sources for cardiac cell therapy
Cardiac Device - Balloon-assisted technique enables closure of large atrial septal defects
Cardiac Drug Therapy - AT1 -receptor antagonists are important CV protective drugs
Cardiac Drug Therapy - Interaction details could lead to drugs with fewer heart-related side effects
Cardiac Fibrosis - Effects of beta-adrenoceptor stimulation on cardiac fibrosis involve aldosterone
Cardiac Fibrosis - Increasing adenylyl cyclase expression could attenuate cardiac fibrosis
Cardiac Hypertrophy - Study examined mechanisms of hypertrophic growth in absence of NPRA signaling
Cardiac Hypertrophy - Yin Yang 1 decreases alpha-MyHC mRNA, protein expression in ventricular myocytes
Cardiac Research - Indices did not demonstrate differences for iNOS-/- mice subjected to MI
Cardiac Research - Nitroxyl is a more potent activator of skeletal ryanodine receptors than NO
Cardiac Surgery - Catheter closure of atrial defects in children is safe, and effective
Cardiac Treatment - Cardiac self-care plays a defining role in time to treatment
Cardiology - Aortic dilation involved the aortic root and the ascending aorta
Cardiology - Cardiac specialty must explore new innovations for the long-term future
Cardiology - Enzyme inhibitors attenuate ventricular dysfunction after pressure overload
Cardiology - Higher baseline pulse pressure associated with CAD progression in older women
Cardiology - Medical technology company promotes dual-chamber pacemakers
Cardiology - Ranolazine is a selective inhibitor of the late sodium current
Cardiology - Real-time 3D Doppler assay devised for pediatric mitral valve flow measurement
Cardiology - Recent findings in cardiology provide new insights
Cardiology - Study evaluated ECG findings of patients with LV hypertrabeculation
Cardiology - Study suggests surgery sooner than later for severe leaky heart valves
Cardiology - Technology co. announces ventricular assist device implanted in 300th patient
Cardiology - Tryptase is proangiogenic in the healing heart
Cardiology - Volume overload and age have combined influence on atrial SERCA2a expression
Cardiothoracic Surgery - Surgeons must work with industry to drive change for cardiothoracic specialty
Cardiovascular Disease - Knowing risk factors, influences could prevent atherosclerosis in renal patients
Cardiovascular Disease - Lower plasma BNP levels may reduce burden on CV system in hemodialysis patients
Cardiovascular Disease - Mechanism may contribute to clinical link between myeloperoxidase and CV disease
Cardiovascular Disease - Pedometer company offers ten tips to keep hearts healthy
Cardiovascular Research - Ingested flavonoids may reverse endothelial dysfunction by enhancing NO activity
Cardiovascular Research - L-type Ca2+ channels are regulated by beta-adrenergic stimulation
Cardiovascular Research - Resveratrol-mediated HO-1 expression occurs through the NF-kappaB pathway
Cardiovascular Research - Trials evaluated the effect of antichlamydial antibiotics on secondary CV events
Cardiovascular Surgery - Safety and efficacy of minimally invasive mitral valve surgery reviewed
Cell Research - Mitochondrial dysfunction causes inhibition of inward rectifier K+ channels
Cerebrovascular Disease - B-type natriuretic peptide, C-reactive protein are independent predictors of CHF
Collaborations - Company signs research agreement with Detroit hospital to target ER care
Congenital Heart Disease - Authors describe approach to define heart failure in congenital heart disease.
Congenital Heart Disease - ENU-induced mutations may yield insights into genetic basis of CHD
Congestive Heart Failure - ACE inhibitors demonstrate a class effect for treatment of patients with CHF
Congestive Heart Failure - Abnormal electrocardiograms linked to heart enlargement
Congestive Heart Failure - NO production and release is progressively impaired in long-term CHF
Congestive Heart Failure - U.S. FDA approval to begin trial for left ventricular assist system granted
Coronary Artery Bypass Surgery - Gender a factor in who gets bypass surgery
Coronary Artery Bypass Surgery - Treatment of combined carotid and coronary artery disease reviewed
Coronary Artery Disease - Predictors of mortality were history of congestive HF, depressed HR variability
Coronary Artery Disease - Therapeutic goals were reached with atorvastatin+amlodipine
Coronary Artery Plaque - Protocol for measuring coronary artery plaque provides high-quality results
Coronary Heart Disease - A three allelic SNP is strongly associated with plasma CRP concentration
Decompensated Heart Failure - More research is needed before nitroglycerin can be a standard therapy for ADHF
Depression - Physicians must be alert for mood disorders in elderly who have lost a spouse
Diabetes - Minorities with diabetes at increased risk for heart disease, stroke
Diabetes Therapy - Recent findings in diabetes therapy provide new insights
Diagnostic Imaging - Postprocessing tools provide a means for quantifying microcirculation
Diagnostics - Researchers describe findings in diagnostics studies
Disease Prevention - Patients active in their healthcare may lower heart disease risk
Drug Development - Novel MAb fragment alters M2 muscarinic acetylcholine receptor activity
Drug Safety - European regulatory body announces action on COX-2 inhibitors
Echocardiography - Hand-held ECG systems can facilitate bedside diagnosis and patient screening
Echocardiography - Left atrial diameter may serve as criterion for HF with pulmonary congestion
Echocardiography - Real-time 3-dimensional echocardiography has a role in measuring stroke volume
End Stage Renal Disease - Specific genes regulate the responses of organ systems affected by ESRD
Endocrinology - L-thyroxine therapy improves lipid-based CVD risk in subclinical hypothyroidism
Endocytosis - Keratinocyte growth factor receptor studied, role of tyrosine residue revealed
Endothelial Dysfunction - Methodology for investigating endothelial dysfunction is still under debate
Environmental Health - Passive smoking kills 30 people a day in the U.K.
Fibrinogen - Method for assays of fibrin permeability may help to study fibrin clot stability
Finance - Cardio-focused medical devices company reports Q4, year ended December 31, 2004
Finance - Cardiology instrument maker reports Q4 and year end 2004 financial results
Finance - Cardiovascular therapy developer raises $40.8 million in private funding round
Finance - Cryotherapy company reports 28% increase in revenue over Q1 2004
Finance - DX-88 and DX-890 maker reports increased net loss
Finance - Maker of device to treat venous reflux disease reports Q4 2004 financial results
Finance - Pharmaceutical company hires banking firm to identify partners, investors
Ganglionitis - Study inventoried immune competent cells in rat cardiac ganglia
Gene Silencing - RNA interference selectively silences angiotensin receptor subtype 1a
Health - Those most at risk are less likely to acknowledge the social gradient in health
Health Promotion - Expert cautions against FDA approval of "race-based" pharmaceutical
Healthcare Coverage - Insurance company enhances critical illness, short term disability products
Heart Disease - Pharmaceutical company announces final results from CLEAR Platelets trial
Heart Disease Prevention - Growing evidence supports focus on mind-body connection in heart disease
Heart Failure - AT1 -receptor blockers have a valuable role in managing heart failure
Heart Failure - Beta-adrenergic receptor-blockers are a cornerstone in managing heart failure
Heart Failure - Candesartan had favorable effect across broad spectrum of heart failure patients
Heart Failure - Lack of trials limits application of differences in B-adrenoreceptor antagonists
Heart Failure - U.S. FDA approves candesartan cilexetil for the treatment of heart failure
Hemodialysis - Trial will compare hemodiafiltration with hemodialysis with respect to CV issues
Histamine Receptors - Norepinephrine exocytosis analyzed, nature of attenuation clarified
Hormone Replacement Therapy - HRT may improve oxidative stress and lipoprotein metabolism in older women
Hypertension - AT-II agonists facilitate systolic BP control and provide CV protection
Hypertension - Increased BP mediated partly by endothelin and ETAR in older female rats
Hypertension - More than 300 new hypertension genes discovered
Hypertension - Patients with malignant phase hypertension have significant cardiac hypertrophy
Hypertension - Small increase in systolic BP may increase the burdens of CV disease
Hypertension Therapy - Efficacy of triple vasopeptide inhibition determined
Hypertrophy - GRKs may be involved in remodeling of cardiac myocytes
Hypoxia - Long-term hypoxia may program the fetus for cerebrovascular disease as an adult
Imaging - Multifrequency driving can enhance echo particle image velocimetry applications
Imaging - Recent advances generate interest in PET to evaluate an array of CV diseases
Implantable Defibrillators - Review on implantable defibrillators highlights risk assessment
Interleukins - Normal platelets possess the soluble form of IL-6 receptor
Ischemia - Hippocampal forebrain ischemia analyzed, XIAP and Smac/DIABLO regulation defined
Ischemic Heart Disease - Climate-based health forecasts could aid coping with harsh winter health effects
Leptin Studies - Assay of renal Na+-ATPase and regulation in obesity conducted
Magnetic Resonance Angiography - MR angiograms were useful in detecting shunt patency, stenosis, and aneurysm
Magnetic Resonance Angiography - Technical developments in MRA have addressed many issues of imaging in children
Metabolic Syndrome - Researchers' data advance metabolic syndrome research
Mycobacterium Xenopi Infection - Mycobacterium xenopi infection developed following heart transplantation
Myocardial Infarction - African Americans receive less aggressive heart attack treatment
Myocardial Infarction - Matrix-embedded marrow cells generate new vessels in ischemic hearts
Myocardial Infarction - Myocardial tissue inhibitors of MMPs play regulatory role in post-MI remodeling
Myocardial Infarction - Pregnancy-related heart attack incidence increases slightly in California
Myocardial Infarction - Survey shows higher percentage of women aware of heart attack signs than in 2004
Myocardial Infarction - Widely used artery clearing device does not help patients during heart attack
Myocardial Infarction - York academics study cardiac rehab shortfall
Myocarditis - Reducing Th1-mediated autoimmune diseases may exacerbate common viral infections
Myocytes - Ginkgo biloba extract is nonselective cation channel modulator in cardiomyocytes
Natural Products - San-Huang-Xie-Xin-Tang studied, effect on hypotension and inflammation shown
Nutrition - Antioxidant effects of olive oil are probably due to its high oleic acid content
Obstetrics - Renal clearance of atenolol and creatinine is increased during pregnancy
Obstetrics - Two DDAH1 haplotypes associated with susceptibility to preeclampsia
Obstetrics - U.S. FDA clear new fetal-health device
Obstructive Sleep Apnea - Obstructive sleep apnea is underdiagnosed and underappreciated in health care
Osteoporosis - Recent findings in osteoporosis provide new insights
Patents - Patent application filed with U.S. PTO for new format of PREVU* Skin Sterol Test
Patents - Pharma company announces new patents
Patents - Pharmaceutical company updates patent litigation regarding antiplatelet drug
Peripheral Arterial Disease - Company begins phase II gene transfer trial for peripheral arterial disease
Peripheral Arterial Disease - Nonsurgical cryotherapy to treat blocked leg arteries is promising, data show
Peripheral Arterial Disease - Review of lipid therapy focuses on functional improvement and symptomatic relief
Personnel - Peter Crosby named chief operating officer by cardiac device company
Platelets - Alteplase inhibits platelet aggregation more than tenecteplase and reteplase
Platelets - Enhanced platelet activation occurs in colorectal cancer patients
Platelets - Sildenafil studied, effect on human platelet secretory function clarified
Polyphenols - Special issue offers overview of evidence of effects of polyphenols on health
Preeclampsia - LMW heparin therapy lowers recurrence rate, provides additional benefits
Preeclampsia - S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper
Protein Signals - Article reviews components of NADPH oxidases in leukocytes and vascular tissue
Receptor Studies - Receptor activation minimizes signaling which leads to hypertrophic responses
Receptor Studies - Studies have identified protease-activated receptors in vasculature and heart
Receptor Studies - Study investigated the effect of AT2 on myocyte contractile function
Renal Dysfunction - Duke researchers uncover genetic link to kidney damage after heart surgery
Resveratrol - Resveratrol's cancer prevention may result from changes in cell cycle progress
Sleep Apnea - Obstructive sleep apnea treatment receives CE Mark, European clearance
Stroke - Enrollment begun in study of relationship atrial high rate episodes and stroke
Stroke - Improvements in care for stroke should focus on lower socioeconomic groups
Stroke - MTHFR allele evaluation will help prevent/reduce morbidity caused by stroke
Stroke - National Stroke Association stroke prevention guidelines offered by center
Stroke - Quality of stroke care makes a profound difference
Surgical Technology - Positive reaction to femoral puncture closure device, developer reports
Thromboembolism Therapy - Dalteparin based on body weight safe for thromboembolism in obesity
Thymectomy - Thymectomy disturbs long-term maintenance of lymphocyte populations
Tobacco Use - First global anti-smoking treaty becomes binding international law
Transdermal Drug Delivery - Efficient iontophoretic timolol transport achieved in vitro
Type 2 Diabetic Glomerulosclerosis - Local prosclerotic IGF-I system may reduce ER-mediated protection against GS
Vascular Smooth Muscles - Vascular smooth muscle cell motility studied, influence of STAT-3 revealed
Vasoconstriction - Study examined the pH sensitivity of P2X receptors
Venous Reflux - Article reports positive result for Closure procedure
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