Heart Failure

CPU 86017 improved cardiac performance in acute and chronic heart failure

Published in Heart Disease Weekly, March 27th, 2005

A recent report describes therapeutic effects of CPU 86017 on acute and chronic congestive cardiac failure mediated by reducing ET-1, NOS and oxidative stress in rats.

According to published research from the People's Republic of China, "CPU 86017, a derivative of berberine, was administered to rats in which acute and chronic heart failure was induced by left coronary artery ligation for 3 hours and 8 weeks, respectively. The rats were divided into the following groups: sham operation, coronary artery ligation (CAL), CAL+ CPU 86017 (80, 40 and 20 mg/kg, ig) and CAL+captopril (60 mg/kg, ig)."

Y.Q. Wang and colleagues of the China Pharmaceutical...

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Source: Heart Disease Weekly (2005-03-27)

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