Ischemia/Reperfusion

Study investigated effects of sildenatil citrate on ischemia reperfusion injury

Published in Heart Disease Weekly, March 27th, 2005

Sildenatil citrate (Viagra) induces cardioprotective effects after ischemia/reperfusion injury in infant rabbits.

According to a study from the United States, "Infants undergoing surgery for congenital heart disease are at risk for myocardial ischemia during cardiopulmonary bypass, circulatory arrest, or low-flow states. The purpose of [our] study was to demonstrate the effects of sildenafil, a selective phospho-diesterase-5 (PDE-5) inhibitor on myocardial functional improvement and infarct size reduction during ischemia/reperfusion injury in infant rabbits."

Y.A. Bremer and colleagues of Virginia Commonwealth University described their study,...

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Source: Heart Disease Weekly (2005-03-27)

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