Myocarditis

IFN-gamma (KO) mice have greater progression to dilated cardiomyopathy and HF

Published in Heart Disease Weekly, March 27th, 2005

Impaired upregulation of CD25 on CD4⁺ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure.

According to scientists in the United States, "Inflammation has been recognized increasingly as a critical pathologic component of a number of heart diseases. A mouse model of autoimmune myocarditis was developed to study the role of immune mediators in the development of cardiac dysfunction. We have found previously that IFN-gamma deficiency promotes inflammation in murine myocarditis. It has been unclear, however, how IFN-gamma deficiency in myocarditis affects cardiac function and what underlying immune mechanisms are...

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Source: Heart Disease Weekly (2005-03-27)

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