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Heart Failure

Researchers find rat useful as reference model for human chronic heart failure

Published in Heart Disease Weekly, June 19th, 2005

Researchers at the University of Paris have used aortic banding in rats to create a reference model for human chronic heart failure.

According to a study from France, "Heart failure is a severe pathology, which has displayed a dramatic increase in the occurrence of patients with chronic heart disease in developed countries, as a result of increases in the population's average age and in survival time. This pathology is associated with severe malnutrition, which worsens the prognosis."

"Although the cachexia associated with chronic heart failure is a well-known complication, there is no reference animal model of malnutrition related to heart failure,"...

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