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Cardioprotection

Inhibiting Na+-Ca2+ exchanger during I/R is cardioprotective

Published in Heart Disease Weekly, July 17th, 2005

A recent report describes cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium.

According to recent research from Japan, "The effect of SEA0400, a novel Na+-Ca2+ exchanger inhibitor, on mechanical and electrophysiological parameters of coronary-perfused guinea-pig right ventricular tissue preparation was examined during no-flow ischemia and reperfusion."

I. Namekata and colleagues of Toho University explained, "Contractile force and action potential duration were decreased during no-flow ischemia, while the resting tension was...

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