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Stem Cell Engraftment

Cardiac function improved via engraftment of enriched embryonic stem cells and other medication

Published in Heart Disease Weekly, March 26th, 2006

Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury.

According to researchers working in the United States, "A major limitation of stem cell transfer is early donor-cell death. [In our report], we seek to enhance myocardial repair following injury through transplantation of cardiomyocyte-enriched human embryonic stem cells (hESC) and recipient treatment with cytoprotective (allopurinol + uricase) and anti-inflammatory (ibuprofen) agents."

"We injected 106 (15% hESC-derived cardiomyocytes) green fluorescent protein (GFP+) hESC in...

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