Heart Disease Weekly
Susan Hasty, Publisher
Table of Contents . . . April 2nd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Heart Disease Weekly | Other Publications
Cardiovascular Disease - In stable angina treatment, ivabradine is the first selective sinus node If channel inhibitor
Cardiovascular Research - Study of human dilated cardiomyopathies opens up with Drosophila cardiac function measurements
Genetics & Genomics - Histidine button engineered into cardiac troponin I protects ischemic and failing hearts
Heart Failure - Chronic heart failure may have pathogenic mechanism interacting between TNF alpha and upregulated P2X6 receptor
Alzheimer Disease - U.S. NIH report on controlling cardiovascular risk, enhancing cognitive function published
Anaphylactic Shock - Patients with omeprazole-induced anaphylaxis benefit from newly designed desensitization protocol
Anesthesia - Regional anesthesia with ropivacaine alone does not affect cardiovascular system
Aneurysm - Aneurysm treatment furthered by a proposed outcome measurement tool
Angina - Angina investigations and therapy are affected by gender bias
Angiology - Adult blood vessels are stabilized by vascular endothelial growth factor
Angiology - Angiotensin-(1-7) enhances antiaggregatory effects of nitroprusside
Angiology - Cardioprotective effect of metallothionein may be studied via induction by cadmium, isoproterenol
Angiology - Coronary vasodilation is induced by adrenomedullin, partially through nitric oxide production increase
Angiology - Degree of endothelial dysfunction is reflected in plasma nitrite concentrations
Angiology - High-dose folic acid does not protect vascular endothelium from IR injury in humans
Angiology - Metabolic syndrome amplifies the LDL-C associated increases in carotid atherosclerosis
Angiology - Neovascular pathology is triggered by reactive oxygen species
Angiology - Vascular diseases may derive from bone morphogenetic protein-2
Angiology - Visceral fat obesity contributes to thoracic aorta tortuosity in poststroke patients
Arthroplasty - Patients with lower limb arthroplasty benefit from self-administered thromboprophylaxis
Atherosclerosis - Coronary heart disease may be indicated by low levels of circulating fibronectin
Atherosclerosis - Hyperglycemia plus inflammation is linked to early carotid atherosclerosis progression
Atherosclerosis - Nanobac Life Sciences announces detection of nanobacteria-like particles in human atherosclerotic plaques
Atherosclerosis - TRAIL-expressing T cells induce muscle cell apoptosis in atherosclerotic plaque
Blood Pressure - Ambulatory blood pressure in women is increased in response to alcohol consumption
Business & Finance - Cardium moves to OTC bulletin board
Business & Finance - WorldHeart reports record sales in Q4 2005, increased demand for Novacor implant kits
Cardiology - Acute CaMKII overexpression increases calcium leakage from cardiac myocytes
Cardiology - Cardiac dysfunction is associated with depression of proteasome activities
Cardiology - During CPR, injuries to the cardiac conduction system occur in limited regions
Cardiology - Epinephrine-induced arrhythmia susceptibility is greater in male than in female rat hearts
Cardiology - Erythropoietin prevents cardiac dysfunction in doxorubicin-induced cardiomyopathy
Cardiology - Findings advance knowledge in cardiology research
Cardiology - Findings in cardiology provide new insights
Cardiology - For atrial fibrillation patients undergoing cardioversion, rapid anticoagulation improves outcome
Cardiology - In refractory atrial fibrillation, oral sotalol results in high rate of sinus rhythm restoration
Cardiology - Myocardial infarction areas improve when implanted with skeletal muscle satellite cells
Cardiology - New HFSA guidelines recommend VADs for treating heart failure patients, Thoratec reports
Cardiology - New findings in cardiology described
Cardiology - Recent findings in cardiology described
Cardiology - Reports describe recent advances in cardiology research
Cardiology - Researchers provide details of new studies and findings in the area of cardiology
Cardiology - Researchers' data advance cardiology research
Cardiology - Researchers' findings advance cardiology research
Cardiology - Researchers' work adds to cardiology body of knowledge
Cardiomyocytes - Cardiac cytoarchitecture in the developing mouse heart is presented
Cardiomyocytes - Complement C5a is essential in the pathogenesis of septic cardiac dysfunction
Cardiomyocytes - Phosphodiesterase-2 activity blunts cardiac inotropy via NO/cGMP-dependent pathway
Cardiomyocytes - Ventricular myocyte contraction is altered by C-type natriuretic peptide, NO in eNOS-/- mice
Cardiovascular Disease - Cardiac rehabilitation is safe and helpful for elderly coronary patients
Cardiovascular Disease - Cardiovascular and metabolic effects of natriuretic peptides reviewed
Cardiovascular Disease - Cardiovascular disease prevention in the elderly is influenced largely by lifestyle practices
Cardiovascular Disease - Cardiovascular disease risk awareness correlates with active prevention measures in women
Cardiovascular Disease - Cardiovascular disease risk was not affected by reduced-fat diet
Cardiovascular Disease - Coronary heart disease and the clinical potential of pharmacogenetics are discussed
Cardiovascular Disease - In diabetic adults in the U.S., aspirin use is increasing
Cardiovascular Disease - In peripheral arterial disease, increased urinary albumin excretion may signal coronary disease
Cardiovascular Disease - Organizational guidelines on cardiovascular disease risk factors may need review and update
Cardiovascular Disease - Patients with peripheral arterial disease have greater upper-limb aerobic power
Cardiovascular Disease - Peripheral arterial disease progression is linked to IL-6 elevation by endothelial cell reactive antibodies
Cardiovascular Disease - Pharmacogenetics of multigenic disease is focus of review
Cardiovascular Disease - Research in cardiovascular disease provides new insights
Cardiovascular Disease - Researchers publish new studies and findings in the area of cardiovascular disease
Cardiovascular Disease - Severe left ventricular dysfunction in left atrial myxoma is reported in two cases
Cardiovascular Research - Early postexercise hypotension is attenuated by caffeine in healthy middle-aged subjects
Cardiovascular Research - RAMP2 is key player in sensitivity of adrenomedullin-induced hypotensive responses via AM1 receptor
Cardiovascular Research - Vasoconstriction, lowered cardiac output are induced by epinephrine infused during hypothermia
Cardioversion - Transthoracic echocardiographic variables predict left atrial appendage thrombus
Cerebral Hemorrhage - In survivors of supratentorial cerebral hemorrhage, ECG abnormalities are likely benign
Chlorthalidone - Chlorthalidone is superior for heart failure prevention, independent of renal function
Chronic Conditions - Study shows Ohioans needlessly suffer because they are not properly caring for chronic conditions
Clinical Trials - Corautus to complete enrollment of patients in phase IIb GENASIS trial in June
Clinical Trials - New pulse generator device treats heart failure patients
Clinical Trials - Phase 1 clinical studies of treatment for peripheral artery disease successfully completed
Collaborations - Cooper Heart and Coriell institutes partner on stem-cell heart research project
Collaborations - HemoSense signs agreement with Reliant to distribute INRatio for home INR testing
Collaborations - Witt, GEMMS form marketing and technology partnership to build cardiovascular care system
Complementary & Alternative Medicine - Diabetic cardiomyopathy prevention by zinc supplement is mediated by cardiac MT levels
Complementary & Alternative Medicine - Diacylglycerol oil supplements may be able to manage obesity in type 2 diabetics
Complicated Anterior Mediastinal Malignancies - Complicated anterior mediastinal malignancies treated by surgical resection
Congenital Heart Disease - Congenital heart disease in pregnant women increases adverse maternal and neonatal events
Congenital Heart Disease - Masimo SET Pulse Oximetry may be valuable tool for diagnosis of congenital heart disease in newborns
Coronary Artery Bypass - Coronary artery bypass grafting outcomes may differ by gender
Coronary Artery Disease - Point Biomedical Corporation's Cardiosphere NDA accepted for review by U.S. FDA
Coronary Heart Disease - Coronary heart disease risk is associated with obesity and physical inactivity
DNA Research - Tetrahydrobiopterin supplementation improves vascular dysfunction in insulin-resistance
Diabetes Complications - Aortic depressor nerves show signs of axonal atrophy in chronic diabetes
Diabetes Complications - Diabetics have higher stroke, graft patency, and lib salvage complication risk postsurgery
Diabetes Complications - Elevated plasma PLTP activity predicts carotid intima-media thickness in type 2 diabetes
Diabetes Complications - Hypertension and diabetic complications independent of ethnic origin
Diabetes Complications - Pioglitazone reduces proinflammatory markers in diabetic nephropathy patients
Diabetes Pathogenesis - Glucose toxicity may contribute to microalbuminuria
Diabetes Research - Diabetics with uncontrolled blood pressure identified using administrative databases
Diabetes Research - Vascular relaxation improved by chronically elevated CO levels
Diagnostics - New data illuminates research in diagnostics
Diet & Nutrition - Dietary cholesterol affects monocyte chemoattractant protein-1 gene expression
Diet & Nutrition - Homocysteine-lowering by B vitamins was maximal in those with B12 deficiency
Diet & Nutrition - Studies advance knowledge in diet & nutrition research
Drug Development - Avant announces TP10 does not meet primary endpoint in phase IIb study in female cardiac patients
Drug Efficacy - Ezetimibe lipid-lowering benefit has been demonstrated, but questions remain
Echocardiography - New findings in the area of echocardiography detailed
Embryonic Stem Cell Therapy - Embryonic stem cells may be used to treat chronic heart failure
End-of-Life Issues - End-stage heart disease high-risk research and competence to consent is considered
Endocrinology - Researchers provide details of new studies and findings in the area of endocrinology
Environmental Health - Congenital heart defects and trichloroethylene-contaminated drinking water are presented in review
Environmental Health - Elderly have higher risk for cardiovascular, respiratory disease from fine particle pollution
Facilities - Edwards Lifesciences breaks ground on heart valve manufacturing facility in Singapore
Finance - Cardiac Science announces pro forma Q4 growth of 9%; GAAP loss due to exceptional charges
Finance - Cleveland Clinic spin-off Symphony Medical raises $6M to develop treatments for AF
Finance - Emageon reports record Q4 revenue of $24.3 million
Finance - NicOx reports revenues increased 442% to EUR 6.5 million in 2005
Finance - StemPath announces CDN$1 million private financing with New Generation Biotechnology
Genetics & Genomics - A1 adenosine receptor stimulation up-regulates phospholamban gene expression
Genetics & Genomics - Promoter polymorphisms are minimally implicated in influence on thrombotic risk markers in elderly
Geriatrics - APO A-V-1131T->C polymorphism frequency linked to morbidity in elderly population
Healthcare Access - Late referral of chronic kidney disease deprives patients of reno- and cardioprotective care
Healthcare Costs - Obesity health care may be more costly due to high life expectancy rate among obese
Heart Failure - Congestive heart failure risk may be predicted by electrocardiographic variables
Heart Failure - Findings in heart failure provide new insights
Heart Failure - In chronic congestive heart failure patients, adjuvant oral doxazosin gave no hemodynamic benefit
Heart Failure - Pathophysiology of heart failure with normal ejection fraction is differentiated via algorithm
Heart Failure - Trajectory of end-stage heart failure is considered in relation to technology and policy
Hematology - Antiphospholipid-mediated thrombosis is the focus of review
Hematology - Human platelets can incorporate, synthesize, and hydrolyze fatty acid ethyl esters
Hematology - In patients positive for anticardiolipin antibody, C-reactive protein level may aid assessment
Hematology - Occlusive arterial thrombosis can be reduced with melagatran + aspirin or clopidogrel
Hemorrhagic Shock - Fluid resuscitation with hemoglobin vesicles modeled in acute hemorrhagic shock
Hepatitis C Virus - Reports advance knowledge in hepatitis C virus research
Hypertension - Hypertension is not associated with leptin in Japanese-Brazilian women
Hypertension - Hypertension, antihypertensive therapy, and erectile dysfunction are focus of review
Hypertension - In hypertensive patients, atenolol impacts central systolic BP less than eprosartan
Hypertension - Systolic hypertension in older persons and complexities in clinical decision making are reviewed
Imaging - Additional myocardial redistribution is demonstrated by 24-hour late thallium-201 imaging
Imaging - During acute cardiovascular events, cholesterol crystals rupture membranes, plaques
Imaging - Findings advance knowledge in imaging research
Imaging - Findings describe new data in imaging research
Imaging - In chronic obstructive pulmonary disease, strain rate imaging can assess right ventricular function
Imaging - New findings in the area of imaging described
Imaging - New imaging techniques for diagnosing coronary artery disease are reviewed
Imaging - Reports advance knowledge in imaging research
Imaging - Research in imaging provides new insights
Influenza - Influenza symptoms receive reduced duration and severity from oseltamivir
Ischemia - After hypoxia-ischemia, carnitine inhibits increases in cerebral carnitine esters and glutamate
Ischemia - Bcl-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury
Ischemia - Cerebral ischemia etiology is linked to increase of blood anticardiolipin antibody
Ischemia - During ischemia, the creatine kinase system may inhibit arrhythmia
Ischemia - Ischemia-reperfusion injury is prevented by trimetazidine
Ischemia - Myocardial infarction is prevented by H11 kinase pre-emptive preconditioning of the heart
Ischemia - Type 3 cerebrovascular reactivity with normal O2 extraction fraction may be transition stage
Lipid Research - Lipoprotein(a) level is increased by fenofibrate therapy
Lung Injuries - Exogenous interleukin-4 lessens hypoxia-induced lung injury
Market Analysis - Over 75% of aneurysms treated by surgical clipping, under 25% with coils; ratio to change
Medical Devices - Greek health ministry approves feasibility trial for rotary ventricular assist device
Medical Devices - Rita Medical Systems launches power injectable peripherally inserted central catheter
Mergers & Acquisitions - MicroVention to be acquired by Terumo Corporation
Mergers & Acquisitions - Terumo acquires MicroVention to enter market of catheter-based cerebral aneurysm treatment
Molecular Biology - Vascular elastin calcification is subject to osteogenic and degenerative control
Myocardial Infarction - Acute myocardial infarction in the elderly is focus of review
Myocardial Infarction - Acute myocardial infarction patients of increased age, comorbidity tend to be excluded from CRT
Myocardial Infarction - For elderly patients with acute ST-elevation myocardial infarction, primary PCI is preferred
Myocardial Infarction - Reperfusion therapy with fibrinolytic agents remains first therapy choice where PCI is unavailable
Myocardial Infarction - Treatment of non-ST-elevation acute coronary syndrome in the elderly is discussed
Obesity Complications - Obesity does not significantly influence accuracy of blood pressure measurements
Obesity Pathogenesis - High adiponectin levels seen in Prader-Willi syndrome as compared with other obesity types
Obesity Pathogenesis - Low blood volume and high peripheral adrenergic constriction shown in obese rat model
Obesity Pathogenesis - New findings in the area of obesity pathogenesis described
Obesity Pathogenesis - New research in the area of obesity pathogenesis detailed
Obesity Pathogenesis - Obese and elderly MA levels linked to insulin sensitivity and protein turnover rates
Obesity Pathogenesis - Reports add new data to obesity pathogenesis research
Ophthalmology - Genentech granted Priority Review for Lucentis use in wet macular degeneration
Pediatric Cardiology - Associated congenital heart disease should not change esophageal-fistula repair strategies
Pediatric Cardiology - Pediatric congenital heart disease patients should be managed using age-based NT-proBNP levels
Pericardial Disease - Large symptomatic pericardial effusion might present as unrecognized cancer
Personnel - Andrew M. Reed, PhD, named VP of technology by CardioTech
Pharmaceutical Research - Two ramipril formulations were compared for bioavailability
Priapism - Superselective transcatheter embolization called useful treatment of high-flow priapism
Proteomics - HDL/apoA-I binding protein is expressed on human macrophages and promotes cholesterol efflux
Pulmonary Medicine - Pulmonary vascular remodeling declines in dominant negative transforming growth factor models
Respiratory Medicine - Coughing and the range and frequency of associated complications are the focus of review
Sleep Apnea - In obstructive sleep apnea, CPAP reduces daytime sleepiness, improves quality of life
Sleep Apnea - Obstructive sleep apnea oral appliances are the focus of review
Sleep Apnea - Sleep disturbances were detected by sleep apnea monitor in craniofacial surgical patients
Statins - Pharmacogenomics of cholesterol-lowering therapy is focus of review
Statins - Studies advance knowledge in statins research
Stem Cell Research - Ischemia may resolve after alpha 4 integrin disruption
Stem Cell Transplantation - Stem cell transplantation studies for myocardial infarction treatment remain unclear
Stroke - Cardio-embolic stroke risk among Blacks and Whites is associated with phosphodiesterase 4D gene
Stroke - Existing studies of apolipoprotein E genotype and stroke are unreliable, meta-analyses reveal
Stroke - Higher lifetime stroke risk for women may be due to longer life expectancy
Stroke - In stroke patients treated with IV tissue plasminogen activator, microbubbles accelerate clot lysis
Stroke - Silent brain infarction is associated with metabolic syndrome as risk factor in healthy people
Surgical Technology - New findings in surgical technology described
Surgical Technology - Noninvasive blood pressure monitor as accurate as A-line catheter, study shows
Surgical Technology - Study shows xenon gas safe in surgery and could help stop nerve-damaging illnesses
Thrombosis - Deep vein thrombosis and pulmonary embolism diagnostic testing in pregnancy are the focus of review
Tobacco Use - Left ventricular diastolic function is impaired by cigarette smoke, but not nicotine gum
Tobacco Use - Pulmonary hypertension may correlate with vascular remodeling in cigarette smokers
Transplant Medicine - Researchers' findings advance transplant medicine research
Type 2 Diabetes - In diabetes, altered control of cutaneous vasodilation may lead to impaired thermoregulation
Type 2 Diabetes - Metformin is not linked to higher lactic acidosis risk in type 2 diabetics
Type 2 Diabetes - New type 2 diabetes candidate marker for progression of microvascular disease discovered
Valve Repair - Outcome of tricuspid valve repair for Ebstein's anomaly in young children examined
Vascular Disease - Forbes Medi-Tech announces launch of cholesterol-lowering milk drink with Reducol
Women's Health - Study shows no increased coronary heart risk with estrogen-alone therapy
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